Ashenhurst JR, Bujarski S, Ray LA. Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol.
As for existing friendships with people who appreciate a sober lifestyle, those personal interactions and bonds will likely be much enriched and deepened.
People with alcohol use disorder have an intense need to consume alcohol. This can negatively affect work, relationships and health. Excessive alcohol use can permanently damage the body, in particular the brain and the liver.